Title : Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Pub. Date : 2003 Oct 31

PMID : 14593182






1 Functional Relationships(s)
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1 We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prolonged survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. tofacitinib Janus kinase 3 Mus musculus