Title : Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter.

Pub. Date : 2004 Jan 23

PMID : 14593115






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutation of residues Thr(453) and Thr(739) in Sp1 (amino acids phosphorylated by ERK) blocked FGF-2 repression of PDGFR-alpha transcription. Threonine mitogen-activated protein kinase 1 Homo sapiens
2 Mutation of residues Thr(453) and Thr(739) in Sp1 (amino acids phosphorylated by ERK) blocked FGF-2 repression of PDGFR-alpha transcription. Threonine mitogen-activated protein kinase 1 Homo sapiens