Title : Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer.

Pub. Date : 2003 Oct

PMID : 14578129






3 Functional Relationships(s)
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1 Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels. Folic Acid thymidylate synthetase Homo sapiens
2 Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels. Folic Acid thymidylate synthetase Homo sapiens
3 Given that individuals with high plasma folate had a better survival outcome with a hazard ratio of 0.68 (0.45-1.03) compared with those with low plasma folate, we conclude that the TS promoter polymorphism may modify both the risk and the survival of CRC; however, these effects do not appear to be mediated through its modulation of biological folate levels. Folic Acid thymidylate synthetase Homo sapiens