Pub. Date : 2003 Nov
PMID : 14576103
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. | Chloramphenicol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4"-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [K(i)] values are shown in parentheses) of 32.0 (7.7) and 48.1 (10.6) microM, respectively. | Chloramphenicol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol. | Chloramphenicol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol. | Chloramphenicol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |