Title : Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Pub. Date : 2004 Jan 9

PMID : 14573616






4 Functional Relationships(s)
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1 We investigated the importance of the two catalytic alpha-isoforms of the 5"-AMP-activated protein kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) and contraction-induced glucose uptake in skeletal muscle. acadesine protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
2 We investigated the importance of the two catalytic alpha-isoforms of the 5"-AMP-activated protein kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) and contraction-induced glucose uptake in skeletal muscle. acadesine protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
3 The results show that alpha2-AMPK is the main donor of basal and AICAR-stimulated AMPK activity and is responsible for AICAR-induced glucose uptake. acadesine protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
4 The results show that alpha2-AMPK is the main donor of basal and AICAR-stimulated AMPK activity and is responsible for AICAR-induced glucose uptake. acadesine protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens