Pub. Date : 2003 Nov 10
PMID : 14568301
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 3 | This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 4 | Norharman inhibited microsomal CYP-related enzyme activities and CO-binding to the CYP heme (50% inhibitory concentration (IC50), 0.07-6.4 microg/ml). | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 5 | Norharman inhibited microsomal CYP-related enzyme activities and CO-binding to the CYP heme (50% inhibitory concentration (IC50), 0.07-6.4 microg/ml). | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 6 | These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 7 | These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 8 | These data clarified that norharman acts as an inhibitor of the CYP-mediated biotransformation of Glu-P-1 via inhibition of O2-binding to CYP heme, and its inhibition of CYP enzymes occurs at much lower concentration than that for its intercalation to DNA. | norharman | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |