Title : Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport.

Pub. Date : 2003 Dec

PMID : 14566973






2 Functional Relationships(s)
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1 Cells from T2D patients, in contrast to those from healthy controls, showed no increase in glucose uptake after ATP stimulation; extracellular ATP caused, however, a similar GLUT1 recruitment to the plasma membrane in both groups. Adenosine Triphosphate solute carrier family 2 member 1 Homo sapiens
2 These results suggest that extracellular ATP plays a role in the modulation of glucose transport via GLUT1, and that the P2Y-dependent GLUT1 activation is deficient in fibroblasts from T2D individuals. Adenosine Triphosphate solute carrier family 2 member 1 Homo sapiens