Title : Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.

Pub. Date : 2003 Nov 7

PMID : 14561525






1 Functional Relationships(s)
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1 In an in vivo study, pretreatment of female rats with SKF525A, an inhibitor of CYPs including CYP3A1, significantly (p < 0.05) enhanced MPA-induced hypercoagulation, whereas pretreatment with phenobarbital, an inducer of CYPs including CYP3A1, reduced it. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus