Pub. Date : 2003 Mar
PMID : 14561177
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of inducible nitric oxide synthase by cAMP-elevating phospho-diesterase inhibitors. | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 2 | Among the numerous genes controlled by cyclic adenosine monophosphate (cAMP)/protein kinase A signalling machinery is the gene encoding the inducible nitric oxide synthase (iNOS), an enzyme catalyzing the synthesis of a highly reactive free radical nitric oxide (NO). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 3 | Among the numerous genes controlled by cyclic adenosine monophosphate (cAMP)/protein kinase A signalling machinery is the gene encoding the inducible nitric oxide synthase (iNOS), an enzyme catalyzing the synthesis of a highly reactive free radical nitric oxide (NO). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 4 | Among the numerous genes controlled by cyclic adenosine monophosphate (cAMP)/protein kinase A signalling machinery is the gene encoding the inducible nitric oxide synthase (iNOS), an enzyme catalyzing the synthesis of a highly reactive free radical nitric oxide (NO). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 5 | Among the numerous genes controlled by cyclic adenosine monophosphate (cAMP)/protein kinase A signalling machinery is the gene encoding the inducible nitric oxide synthase (iNOS), an enzyme catalyzing the synthesis of a highly reactive free radical nitric oxide (NO). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 6 | A feasible way for cAMP-dependent therapeutic control of inflammation, including iNOS-mediated NO synthesis, could involve the administration of drugs that block the enzymatic activity of cAMP-degrading phosphodiesterases (PDE). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 7 | A feasible way for cAMP-dependent therapeutic control of inflammation, including iNOS-mediated NO synthesis, could involve the administration of drugs that block the enzymatic activity of cAMP-degrading phosphodiesterases (PDE). | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 8 | Indeed, cAMP-elevating PDE inhibitors can influence iNOS activation in different cell types in vitro, and their potent anti-inflammatory effects in experimental disease models and clinical studies were frequently accompanied with profound modulation of NO production. | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 9 | A set of conflicting data has been generated over the years, ranging from strong suppression to marked enhancement of NO release by cAMP-increasing PDE inhibitors, depending on cell-type, iNOS stimuli, and/or the agents used. | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |
| 10 | The present review summarizes the data on iNOS modulation by cAMP-elevating PDE inhibitors and possible mechanisms behind it, speculating on its contribution to the therapeutic effects of these drugs. | Cyclic AMP | nitric oxide synthase 2 | Homo sapiens |