Title : Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

Pub. Date : 2003 Nov

PMID : 14560023






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 This phosphorylation inhibited phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) binding to PKB, thereby preventing activation of the kinase by insulin. pip(3) insulin Homo sapiens