Pub. Date : 2003 Nov
PMID : 14559856
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 potentiates NGF-induced neurite outgrowth via the Ras/Raf/MAP kinase pathway. | Tacrolimus | zinc fingers and homeoboxes 2 | Homo sapiens |
| 2 | Inhibitors of Ras (lovastatin), Raf (GW5074), or MAP kinase (PD98059 and U0126) blocked FK506 activity, as did inhibitors of phospholipase C (U73122) and phosphatidylinositol 3" kinase (LY294002). | Tacrolimus | zinc fingers and homeoboxes 2 | Homo sapiens |
| 3 | These data suggest that FK506 potentiates neurite outgrowth through the Ras/Raf/MAP kinase signaling pathway downstream of phospholipase C and phosphatidylinositol 3" kinase. | Tacrolimus | zinc fingers and homeoboxes 2 | Homo sapiens |