Title : Arsenic trioxide-induced apoptosis of human malignant lymphoma cell lines and its mechanisms.

Pub. Date : 2003 Oct

PMID : 14559676






2 Functional Relationships(s)
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1 As2O3-induced apoptosis was accompanied by down-regulation of Bcl-xL protein expression and activation of apoptosis protein caspase-3, as identified by Western blotting. Arsenic Trioxide BCL2 like 1 Homo sapiens
2 CONCLUSION: As2O3 exerts apoptosis-inducing effects on human Burkitt lymphoma cells through down-regulation of Bcl-xL protein expression and activation of apoptosis protein caspase-3, and may serve as a candidate therapeutic agent against malignant lymphoma for both systemic and local therapies. Arsenic Trioxide BCL2 like 1 Homo sapiens