Title : Exploring selectivity requirements for COX-2 versus COX-1 binding of 3,4-diaryloxazolones using E-state index.

Pub. Date : 2003 Nov 3

PMID : 14552773






1 Functional Relationships(s)
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1 The study also shows the utility of E-state index in developing statistically acceptable model having direct physicochemical significance: electron density distribution of different atoms of the oxazolone ring and attached two phenyl rings are important for the selective binding with COX-2 over COX-1. Oxazolone mitochondrially encoded cytochrome c oxidase II Homo sapiens