Title : Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons.

Pub. Date : 2003 Sep

PMID : 14550768






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
3 Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
4 Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
5 These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
6 These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens