Title : Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.

Pub. Date : 2003 Nov

PMID : 14533013






1 Functional Relationships(s)
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1 Increase of collagen synthesis induced by raloxifene may be activated by both estrogen receptor dependent and independent pathways such as up-regulation of estrogen receptors, up-regulation of IGF receptor, transcriptional regulation of collagen genes by estrogen receptor-raloxifene complex, increasing of prolidase activity or finally by inhibition of MMP-9 expression. Raloxifene Hydrochloride peptidase D Homo sapiens