Title : The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin.

Pub. Date : 2003 Dec 19

PMID : 14530262






1 Functional Relationships(s)
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1 The NO donor 3-morpholinosydnonimine, HCl (SIN-1) and 8-bromo-guanosine 3",5"-cyclic monophosphate (8-Br-cGMP) functionally desensitized U46619-mediated calcium mobilization and inositol 1,4,5-trisphosphate generation by TP alpha whereas signaling by TP beta was unaffected by either agent. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Homo sapiens