Title : Anticancer antifolates: current status and future directions.

Pub. Date : 2003

PMID : 14529544






1 Functional Relationships(s)
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1 Thus in rational design and in structure-based design studies, two new classes of antifolate enzyme inhibitors were elaborated-direct inhibitors of thymidylate synthase (TMPS) and direct inhibitors of one or both of the two folate-dependent enzymes of de novo purine synthesis. Folic Acid thymidylate synthetase Homo sapiens