Title : Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis.

Pub. Date : 2003 Oct

PMID : 14528517






2 Functional Relationships(s)
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1 FK506 caused a marked reduction of TNF-a and IL-1beta levels in paw tissue even in short-term (3-day) therapeutic treatment. Tacrolimus tumor necrosis factor Rattus norvegicus
2 CONCLUSION: FK506 is more effective than MTX in reducing elevated levels of inflammatory cytokines TNF-a, IL-1beta, and IL-6 in established stages of AIA. Tacrolimus tumor necrosis factor Rattus norvegicus