Pub. Date : 2003 Oct 14
PMID : 14523244
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, the Abl kinase inhibitor imatinib mesylate (Gleevec, or STI571), which targets the ATP-binding site of Abl and several other tyrosine kinases, potently reduces Abeta production in the N2a cell-free system and in intact N2a cells. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | In addition, the Abl kinase inhibitor imatinib mesylate (Gleevec, or STI571), which targets the ATP-binding site of Abl and several other tyrosine kinases, potently reduces Abeta production in the N2a cell-free system and in intact N2a cells. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | Both STI571 and a related compound, inhibitor 2, also reduce Abeta production in rat primary neuronal cultures and in vivo in guinea pig brain. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | Furthermore, production of Abeta and its inhibition by STI571 were demonstrated to occur to similar extents in both Abl-/- and WT mouse fibroblasts, indicating that the effect of STI571 on Abeta production does not involve Abl kinase. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |
| 5 | Furthermore, production of Abeta and its inhibition by STI571 were demonstrated to occur to similar extents in both Abl-/- and WT mouse fibroblasts, indicating that the effect of STI571 on Abeta production does not involve Abl kinase. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |
| 6 | The efficacy of STI571 in reducing Abeta without affecting Notch-1 cleavage may prove useful as a basis for developing novel therapies for Alzheimer"s disease. | Imatinib Mesylate | amyloid beta (A4) precursor protein | Mus musculus |