Title : The role of chemotherapy in brain metastases.

Pub. Date : 2003 Oct

PMID : 14522368






1 Functional Relationships(s)
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1 Cytochrome P450 3A4 inducing anti-epileptic drugs like phenytoin, carbamazepine and phenobarbital may significantly increase the metabolism of many chemotherapeutic agents like CPT11 and paclitaxel (but also of newer biological agents like many tyrosine kinase inhibitors). Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens