Title : Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin.

Pub. Date : 2003 Oct 24

PMID : 14519449






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Analog A, which bears an alkene moiety between C-1 and C-14, a ketone at the C-2 position, and an alkyne moiety between C-3 and C-4, had the greatest anti-adhesive effect. Alkenes heterogeneous nuclear ribonucleoprotein C Homo sapiens
2 Change of the alkene between C-1 and C-14 to an alkane (analog I) decreased the anti-adhesive effect by 2.5-4 fold, while substitution of ketone by hydroxyl (analog G) at the C-2 position caused an 11-fold decrease in the anti-adhesive effect. Alkenes heterogeneous nuclear ribonucleoprotein C Homo sapiens