Title : RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.

Pub. Date : 2003 Oct 7

PMID : 14516190






3 Functional Relationships(s)
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1 RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Aminoglycosides Rev Human immunodeficiency virus 1
2 Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). Aminoglycosides Rev Human immunodeficiency virus 1
3 All the modified aminoglycosides exhibit a high affinity for the Rev binding site on the RRE (K(d) <or= 10 nM), but few compounds have a high specificity for the RRE. Aminoglycosides Rev Human immunodeficiency virus 1