Title : Gadd153 restores resistance to radiation-induced apoptosis after thiol depletion.

Pub. Date : 2003 Oct 10

PMID : 14511657






2 Functional Relationships(s)
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1 Among other genes we found the transcription factor Gadd153 to be upregulated after exposing the cells to cystine/methionine free culture medium. Methionine DNA damage inducible transcript 3 Homo sapiens
2 We found that overexpression of Gadd153 slightly reduced the amount of radiation-induced apoptosis in cells kept in normal medium but very significantly reduced apoptosis (from 55% to 18%) in cells which were treated with cystine/methionine free culture medium. Methionine DNA damage inducible transcript 3 Homo sapiens