Pub. Date : 2003 Oct 10
PMID : 14511643
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study shows that 2-week exposure of human glomerular endothelial cells to high glucose (22 mM) determines a highly significant increase in DPP-IV activity and mRNA expression, which cannot be entirely accounted for by hyperosmolarity. | Glucose | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | On the other hand, incubation of purified DPP-IV in a buffer solution added with high glucose does not affect enzyme activity. | Glucose | dipeptidyl peptidase 4 | Homo sapiens |
| 3 | These results suggest that high glucose increases expression and activity of DPP-IV, possibly contributing to GLP-1 reduction in type 2 diabetic patients. | Glucose | dipeptidyl peptidase 4 | Homo sapiens |