Title : Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.

Pub. Date : 2004 Feb 1

PMID : 14510637






1 Functional Relationships(s)
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1 With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens