Pub. Date : 2004 Feb 1
PMID : 14510637
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%. | Ibuprofen | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition. | Ibuprofen | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |