Title : Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin.

Pub. Date : 2003 Oct 1

PMID : 14505797






1 Functional Relationships(s)
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1 The carboxy form of many CPTs, including 9AC, preferentially binds to human serum albumin (HSA), which further reduces the equilibrium amount of active lactone and greatly decreases antitumor efficacy. Lactones albumin Homo sapiens