Pub. Date : 2003 Dec 5
PMID : 14504283
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. | Androstenedione | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase reactions. | Androstenedione | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | In contrast, mutation E305G exhibits 11-fold greater catalytic efficiency (kcat/Km) for the cleavage of 17alpha-hydroxyprogesterone to androstenedione compared with wild-type CYP17. | Androstenedione | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |