Title : Interferon-mediated intracellular signalling. Modulation of different phospholipase activities in Burkitt lymphoma cells.

Pub. Date : 1992 Nov 30

PMID : 1446736






2 Functional Relationships(s)
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1 Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway. Phosphatidylinositol 4,5-Diphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens