Pub. Date : 1992 Oct 30
PMID : 1433219
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 2 | Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 3 | The nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 4 | The nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 5 | In an attempt to develop novel mechanism-based inactivators of MAO-B, we have synthesized analogs of MPTP bearing a variety of functional groups at either the N or the C(4) position and have examined their interactions with a purified MAO-B preparation isolated from beef liver. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |