Title : Double-blind randomized phase I study on the clinical tolerance and biological effects of natural and recombinant interferon-beta.

Pub. Date : 1992 Oct

PMID : 1431312






3 Functional Relationships(s)
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1 The clinical tolerance of and the effects recombinant human interferon-beta (rHuIFN-beta) obtained from mammalian cells (Chinese hamster ovary cells) exerts on 2",5"-oligoadenyl (2-5A) synthetase activity, human-Mx protein, neopterin, beta 2-microglobulin, interleukin-1 (IL-1) alpha and beta synthesis were compared to those of natural IFN-beta in 12 healthy volunteers. Neopterin interferon beta 1 Homo sapiens
2 The clinical tolerance of and the effects recombinant human interferon-beta (rHuIFN-beta) obtained from mammalian cells (Chinese hamster ovary cells) exerts on 2",5"-oligoadenyl (2-5A) synthetase activity, human-Mx protein, neopterin, beta 2-microglobulin, interleukin-1 (IL-1) alpha and beta synthesis were compared to those of natural IFN-beta in 12 healthy volunteers. Neopterin interferon beta 1 Homo sapiens
3 Moreover, rHuIFN-beta and natural IFN-beta induced significant and similar increases in 2"-5" adenylates, human Mx protein, and neopterin levels, but neither modulated beta 2-microglobulin, IL-1 alpha or beta synthesis. Neopterin interferon beta 1 Homo sapiens