Title : 13C NMR studies of complexes of Escherichia coli dihydrofolate reductase formed with methotrexate and with folic acid.

Pub. Date : 1992 Nov 9

PMID : 1426244






2 Functional Relationships(s)
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1 Addition of either NADP+ or NADPH to the E. coli DHFR-MTX complex results in a single set of 13C signals for bound methotrexate consistent with only one conformational form in the ternary complexes. NADP dihydrofolate reductase Escherichia coli
2 Addition of either NADP+ or NADPH to the E. coli DHFR-MTX complex results in a single set of 13C signals for bound methotrexate consistent with only one conformational form in the ternary complexes. NADP dihydrofolate reductase Escherichia coli