Pub. Date : 1992 Nov
PMID : 1425417
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone. | 8-Bromo Cyclic Adenosine Monophosphate | interleukin 1 complex | Mus musculus |
| 2 | Treatment with 8-Br-cAMP plus 0.2 and 2 U/ml IL-1 decreased testosterone production to 63 +/- 14% and 41 +/- 19%, respectively, while 5, 10, and 20 U/ml IL-1 decreased testosterone production to less than 5% that of cells treated with 8-Br-cAMP alone. | 8-Bromo Cyclic Adenosine Monophosphate | interleukin 1 complex | Mus musculus |
| 3 | IL-1 caused a dose-dependent decrease in 8-Br-cAMP-stimulated P450c17 levels (0.2 U/ml by 31 +/- 9%, 2 U/ml by 82 +/- 12%, and 10 or 20 U/ml by 100% compared to that in cells treated with 8-Br-cAMP alone). | 8-Bromo Cyclic Adenosine Monophosphate | interleukin 1 complex | Mus musculus |
| 4 | Within 12 h after the removal of IL-1, P450c17 mRNA was restored to 24%; after 24 h, to 36%; after 36 h, to 65%; and after 48 h, to 84% of that with 8-Br-cAMP alone. | 8-Bromo Cyclic Adenosine Monophosphate | interleukin 1 complex | Mus musculus |