Title : Effects of serotonin on intracellular pH and contraction in vascular smooth muscle.

Pub. Date : 1992 Dec

PMID : 1423928






2 Functional Relationships(s)
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1 In HCO3(-)-free buffer (pHo 7.4), 5-HT (10(-5) M) increased pHi, as measured by 2",7"-bis(2-carboxyethyl)-5(6)-carboxyfluorescein fluorescence, from 7.10 +/- 0.03 to 7.34 +/- 0.03 (p < 0.01) in primary cultures of canine femoral artery vascular smooth muscle cells grown to confluence in the presence of 10% fetal calf serum. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus
2 In HCO3- buffer (24 mM, pHo 7.4), resting pHi was 7.26 +/- 0.04 (p < 0.01 versus HCO3(-)-free buffer) but was not altered by 5-HT. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus