Title : Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.

Pub. Date : 1992 Oct

PMID : 1423839






1 Functional Relationships(s)
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1 The relatively high contribution of P450 2A6 to the activation of NDEA and NNK was supported by the correlation seen with coumarin 7-hydroxylation in human liver microsomes, and antibodies raised against P450 2A6 inhibited both activities by approximately 50%. coumarin cytochrome P450 family 2 subfamily B member 6 Homo sapiens