Title : Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives.

Pub. Date : 1992 Apr

PMID : 1411635






2 Functional Relationships(s)
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1 The superior efficacy without increased toxicity of more prolonged schedules of etoposide administration has been demonstrated recently in patients with small cell lung cancer (SCLC). Etoposide SCLC1 Homo sapiens
2 Although the optimal schedule in any specific tumor is not known, current pharmacodynamic evidence suggests that the efficacy of etoposide, at least in SCLC, is related to the maintenance of prolonged low blood concentrations of drug. Etoposide SCLC1 Homo sapiens