Title : Substrate specificity of small-intestinal lactase. Assessment of the role of the substrate hydroxyl groups.

Pub. Date : 1992 Oct 1

PMID : 1396715






2 Functional Relationships(s)
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1 With respect to the galactose moiety, it is shown here that HO-3" and HO-2" are necessary for hydrolysis of the substrates by lactase. Galactose lactase Homo sapiens
2 Using these chemically modified substrates, it has been confirmed that lactase does not behave as a typical beta-galactosidase, since it does not show an absolute selectivity with respect to substitution and stereochemistry at C4" in the galactose moiety of the substrate. Galactose lactase Homo sapiens