Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

Pub. Date : 1992 Oct

PMID : 1396557






1 Functional Relationships(s)
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1 We propose that binding of acetylcholine, on the surface of AChE, may trigger sequence of conformational changes extending from the peripheral anionic site through W286 to D74, at the entrance of the "gorge", and down to the catalytic center (through Y341 to F338 and Y337). Acetylcholine acetylcholinesterase (Cartwright blood group) Homo sapiens