Pub. Date : 1992
PMID : 1389683
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression by retinoic acid of epidermal growth factor receptor autophosphorylation and glycosylation in cultured human head and neck squamous carcinoma cells. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 2 | Here we examined the effects of RA on the expression and function of EGF-R in two HNSCC cell lines, 1483 and 183, which exhibit distinct states of squamous cell differentiation, EGF-R mRNA levels, and responses to the growth inhibitory effects of RA. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 3 | Treatment with RA (1 microM, 7 days) of the RA-sensitive 1483 cells decreased the level of EGF-R mRNA two- to four-fold and the binding of 125I-EGF to the cell surface by 30%-35%. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 4 | Other effects of RA on EGF-R structure and function were similar in both cell lines. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 5 | More important, RA treatment of both cell lines decreased EGF-R autophosphorylation activity detected in immune-complex-kinase assay by about three- and five-fold in the 1483 and 183 cells, respectively. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 6 | Likewise, RA decreased the glycosylation of EGF-R in both cell lines. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 7 | These results demonstrate that RA can modify the structure of the EGF-R by decreasing its glycosylation and suggest that these changes may suppress the autophosphorylation activity of the receptor kinase. | Tretinoin | epidermal growth factor receptor | Homo sapiens |
| 8 | The RA-induced changes in EGF-R do not correlate with the effect of RA on the growth of the cells but may be related to the suppression of squamous cell differentiation in the 1483 cells. | Tretinoin | epidermal growth factor receptor | Homo sapiens |