Pub. Date : 1992 May
PMID : 1388255
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the mouse, administration of corticosterone-21-acetate (30 mg/kg, s.c. daily) for 3 and 10 days produced an attenuation of the hypothermic response to the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), which was not present after administration for 1 day. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | The serotonin syndrome was also induced in mice using 8-OH-DPAT; this increased in a dose-dependent manner and could be significantly decreased by pre-treatment with 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)-piperazine (NAN-190 5 mg/kg, i.p., 30 min prior to administration of 8-OH-DPAT), a 5-HT1A receptor antagonist. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |