Pub. Date : 1992 Jul
PMID : 1388136
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 2 | TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 3 | Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 4 | Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 5 | Ionomycin synergized with TPA in increasing the expression of PKC alpha and PKC beta mRNA. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 6 | Moreover, the combined effects of TPA and ionomycin on T-cell function and cell-surface antigen expression appear to be due, at least in part, to their synergistic activation of distinct PKC isoenzyme(s). | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |