Pub. Date : 1992 May
PMID : 1385797
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells. | Pentoxifylline | interleukin 6 | Homo sapiens |
| 2 | Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells. | Pentoxifylline | interleukin 6 | Homo sapiens |
| 3 | In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6). | Pentoxifylline | interleukin 6 | Homo sapiens |
| 4 | In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6). | Pentoxifylline | interleukin 6 | Homo sapiens |
| 5 | Indeed, PTX at high concentrations triggers the production of IL-6 but not of TNF-alpha by peripheral blood mononuclear cells (PBMC). | Pentoxifylline | interleukin 6 | Homo sapiens |
| 6 | Further experiments indicated that monocytes are responsible for this PTX-induced IL-6 production. | Pentoxifylline | interleukin 6 | Homo sapiens |
| 7 | In addition, the in vivo administration of PTX in transplant patients receiving the first dose of OKT3 allowed to decrease the systemic release of TNF-alpha but not of IL-6. | Pentoxifylline | interleukin 6 | Homo sapiens |
| 8 | In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells. | Pentoxifylline | interleukin 6 | Homo sapiens |
| 9 | We suggest that cAMP could be involved in these differential effects of PTX on production of TNF-alpha and of IL-6. | Pentoxifylline | interleukin 6 | Homo sapiens |