Title : Epitope analysis of aztreonam by antiaztreonam monoclonal antibodies and possible consequences in beta-lactams hypersensitivity.

Pub. Date : 1992

PMID : 1384868






2 Functional Relationships(s)
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1 Three cell lines producing monoclonal antibodies, Az-1 (IgG1), Az-2 (IgG1) and Az-3 (IgM) against aztreonam were established. Aztreonam ornithine decarboxylase antizyme 3 Homo sapiens
2 Furthermore, the MAb showed no inhibitory reaction with various beta-lactams except aztreonam- and ceftazidime-EACA conjugates in the ELISA inhibition test, suggesting that Az-3 recognize a new antigenic determinant (NAD), which is formed by the conjugation of beta-lactam and carrier protein. Aztreonam ornithine decarboxylase antizyme 3 Homo sapiens