Title : Phenotype-specific "tissue" transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: correlation with cell death by apoptosis.

Pub. Date : 1992 Sep 9

PMID : 1381704






6 Functional Relationships(s)
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Protein Name
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1 Phenotype-specific "tissue" transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: correlation with cell death by apoptosis. Tretinoin transglutaminase 2 Homo sapiens
2 However, we recently showed that, during the RA treatment, a subset of SK-N-BE(2) cells undergo apoptosis; these cells specifically express a high "tissue" transglutaminase (tTG) level. Tretinoin transglutaminase 2 Homo sapiens
3 However, we recently showed that, during the RA treatment, a subset of SK-N-BE(2) cells undergo apoptosis; these cells specifically express a high "tissue" transglutaminase (tTG) level. Tretinoin transglutaminase 2 Homo sapiens
4 In fact, RA treatment enhanced tTG expression and apoptotic index in the flat substrate-adherent variant, whereas, in cells expressing the neural phenotype, very low tTG expression and apoptosis were found. Tretinoin transglutaminase 2 Homo sapiens
5 An increase in tTG mRNA major transcript levels (3.7 kb) occurred within a few hours of exposure to RA in both the phenotypic variants. Tretinoin transglutaminase 2 Homo sapiens
6 By contrast, tTG protein level was very low in the cell expressing the neuronal phenotype, even after prolonged exposure to RA. Tretinoin transglutaminase 2 Homo sapiens