Title : Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis.

Pub. Date : 1992 Aug 1

PMID : 1379736






2 Functional Relationships(s)
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1 Phosphorylation of pp60c-src by p34cdc2 at three amino-proximal serine/threonine residues is temporally correlated with, but insufficient for, mitotic activation of c-Src kinase. Threonine cyclin dependent kinase 1 Homo sapiens
2 We conclude that p34cdc2 partially activates pp60c-src by a two-step process in which its serine/threonine phosphorylations either sensitize pp60c-src to a Tyr-527 phosphatase or desensitize it to a Tyr-527 kinase. Threonine cyclin dependent kinase 1 Homo sapiens