Title : Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP.

Pub. Date : 1992

PMID : 1379363






3 Functional Relationships(s)
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1 The current work reports a detailed study of PSA glycoprotein expression as influenced by steroid hormones in a human prostatic adenocarcinoma cell line, LNCaP. Steroids kallikrein related peptidase 3 Homo sapiens
2 The mutation and alteration of steroid-binding specificity of the androgen receptor is also correlated with PSA glycoprotein expression affected by different ligands tested. Steroids kallikrein related peptidase 3 Homo sapiens
3 Therefore, we conclude that the PSA glycoprotein expression is influenced predominantly by androgens via its receptor, and the mutation of the receptor can affect the expression of this cellular gene by the steroids other than androgens. Steroids kallikrein related peptidase 3 Homo sapiens