Title : RANTES, a monocyte and T lymphocyte chemotactic cytokine releases histamine from human basophils.

Pub. Date : 1992 Jul 15

PMID : 1378073






7 Functional Relationships(s)
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1 In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine. Histamine C-C motif chemokine ligand 2 Homo sapiens
2 In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine. Histamine C-C motif chemokine ligand 2 Homo sapiens
3 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine C-C motif chemokine ligand 2 Homo sapiens
4 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine C-C motif chemokine ligand 2 Homo sapiens
5 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine C-C motif chemokine ligand 2 Homo sapiens
6 Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min. Histamine C-C motif chemokine ligand 2 Homo sapiens
7 Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min. Histamine C-C motif chemokine ligand 2 Homo sapiens