Title : Antigen-independent pathways of T-cell activation are functional in human immature thymocytes.

Pub. Date : 1992

PMID : 1375518






2 Functional Relationships(s)
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1 We found that CD1+CD3- cells proliferate upon stimulation with anti-CD28 monoclonal antibody as well as with a pair of anti-CD2 monoclonal antibodies in the presence of low doses (0.5 ng/ml) of phorbol-13-myristate-12-acetate and/or recombinant interleukin-2. phorbol-13-myristate-12-acetate CD1c molecule Homo sapiens
2 A minor fraction of CD3+ cells (15%-20%) was also present in the proliferating cell population originating from CD1+CD3- thymocytes stimulated with phorbol-13-myristate-12-acetate and recombinant interleukin-2, either in the presence or in the absence of specific monoclonal antibodies. phorbol-13-myristate-12-acetate CD1c molecule Homo sapiens