Title : Cyclic AMP does not inhibit collagen-induced platelet signal transduction.

Pub. Date : 1992 May 1

PMID : 1375452






1 Functional Relationships(s)
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1 However, we report here that while signal transduction induced by ADP plus a thromboxane mimetic (U46619), or by thrombin, is inhibited by stimulators of adenylate cyclase such as a prostaglandin I2 (PGI2) analogue (Iloprost), PGD2 and forskolin, elevation of cyclic AMP does not inhibit either platelet adhesion to collagen or the associated Ca2+ mobilization, phosphatidic acid formation or 5-hydroxytryptamine secretion. Colforsin coagulation factor II, thrombin Homo sapiens