Title : The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats.

Pub. Date : 1992 May

PMID : 1374948






3 Functional Relationships(s)
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1 FK506 pretreatment significantly reduced the serum levels of BUN (P less than 0.02), creatinine (P less than 0.02), and TNF (P less than 0.05) as compared with that seen in controls. Tacrolimus tumor necrosis factor Rattus norvegicus
2 Based upon these data, it can be concluded that (1) FK506 pretreatment ameliorates the functional renal injury associated with I/R, (2) renal ischemia induces the release of TNF, and (3) FK506 pretreatment results in a significant inhibition of TNF production. Tacrolimus tumor necrosis factor Rattus norvegicus
3 Based upon these data, it can be concluded that (1) FK506 pretreatment ameliorates the functional renal injury associated with I/R, (2) renal ischemia induces the release of TNF, and (3) FK506 pretreatment results in a significant inhibition of TNF production. Tacrolimus tumor necrosis factor Rattus norvegicus